Dichiarazione del Presidente Mattarella in occasione della Giornata internazionale contro la corruzione

Il Presidente della Repubblica, Sergio Mattarella, in occasione della Giornata internazionale contro la corruzione, ha rilasciato la seguente dichiarazione:

« Sconfiggere la corruzione continua ad essere tra gli impegni primari del Paese e, affinché l’azione di contrasto sia efficace, è indispensabile, accanto all’impegno delle istituzioni centrali e locali, il contributo di ciascun cittadino e dei soggetti economici e sociali.

La corruzione può essere combattuta soltanto attraverso il convinto coinvolgimento etico e culturale di ciascuno nella società, diretto ad affermare, senza esitazioni o timidezze, il primato della legalità, non essendo esaustiva la repressione penale.

Chiarezza delle norme, trasparenza e imparzialità dell’azione amministrativa sono i pilastri portanti dello Stato democratico, senza i quali non può essere assicurata la uguaglianza e il leale rapporto con i cittadini.

Le istituzioni, per prime, devono assolvere al dovere di affermare il valore dell’onestà.

Il Parlamento ha profuso serio impegno nella elaborazione di leggi dirette a realizzare questi obiettivi, valorizzando anche le migliori pratiche di trasparenza, integrità e anticorruzione sperimentate dalle imprese italiane. La corruzione rappresenta un fattore di rallentamento della competitività e della produttività, danneggia gravemente il sistema economico, impedendo la valorizzazione delle elevate professionalità che il nostro paese vanta, influisce negativamente sui traffici e le relazioni internazionali.

L’azione sviluppata dalle istituzioni, dalla Magistratura e dalle Forze dell’Ordine, impegnate nella prevenzione e nel contrasto all’illegalità, produce indubbiamente effetti positivi e, tuttavia, è anzitutto sull’integrità e sulla responsabilità di ciascuno che si costruisce quotidianamente una società sana.

L’odierna Giornata mondiale anticorruzione costituisce un’importante occasione per ribadire l’esigenza di diffondere la cultura della legalità nell’arena internazionale ».

Roma, 9 dicembre 2017

Tratto da www.quirinale.it.
L’utilizzazione, la riproduzione, l’estrazione di copia, ovvero la distribuzione delle informazioni testuali, degli elementi multimediali e del patrimonio iconografico e simbolico del Segretariato Generale della Presidenza della Repubblica e degli Uffici e Servizi ad esso connessi, disponibili su questo sito, sono autorizzate esclusivamente nei limiti in cui le stesse avvengano nel rispetto dell’interesse pubblico all’informazione, per finalità non commerciali, garantendo l’integrità degli elementi riprodotti e mediante indicazione della fonte.

(Visited 2 times, 1 visits today)

Caliban by the Yellow Sands by MACKAYE, Percy

Caliban, the primitive, savage son of the witch Sycorax and the evil frog-tiger god Setebos, seeks to obtain knowledge and become civilized from a strange magician named Prospero and his young daughter, Miranda. Through fantastic visions (including of Shakespeare plays), poetry, song and dance, thus begins the slow, gradual education of a inquisitive brute as he faces enlightenment and wicked temptation.

Serving as a thematic companion piece and maybe spiritual prequel and midquel to William Shakespeare’s [i]The Tempest[/i], [i]Caliban by the Yellow Sands[/i] was a massive, elaborate and outdoor “community masque” performed from 1916-1917 in New York and Boston as part of the three-hundredth anniversary of Shakespeare’s death. Preaching an anti-war message in response to the current events of World War I, it was a smashing success, as it was seen by over two hundred thousand spectators and utilized 1500 amateur artisans and actors to bring its giant vision to life. Summary by Mary Kay

Cast List:

Narrator: Amelia Chesley
Caliban: Craig Franklin
Miranda: Kieren Metts
Prospero: ToddHW
Ariel: Kristin Gjerløw
Voices from Below / Power of Setebos / All / The Dirge / The Soldiers: Tomas Peter
Voices from Within / Spirits of Ariel / All / The Chorus: MaryAnn
Sycorax / Cleopatra / Juliet / War / The Voice / Mrs. Page: Sonia
Cressida / Charmian / Perdita / Lust / The Emperor / Mrs. Quickly / The Spirit of Time: Lian Pang
Antony / Troilus / Horatio / Benvolio / Adam / Sir John Falstaff: alanmapstone
Pandarus / Ghost of Caesar / Hamlet / Mercutio / Lorenzo / The Duke / Sir Hugh Evans / King Henry the Fifth: Larry Wilson
Attendant / Brutus / Florizel / Marcellus / Romeo / Orlando / Pistol: Dafni Ma
Eros / The Boy / Lucius / Death / Jacques / Mrs. Ford: Leanne Yau
This title is avalable for free download at: www.librivox.org.

(Visited 3 times, 1 visits today)

Love Affairs of the Courts of Europe by HALL, Thornton

The best stories are written by life itself, and that is why Thornton Hall has collected real life love stories in this volume. All the Princes Charming and the Fair Maidens of these stories are historical figures, which have at one time played their roles at one of the many Courts of Europe. Hall’s writing style is entertaining and easy to follow, and though he may be guilty of embellishing the stories, the flourishes only add to their charm. – Summary by Carolin
This title is avalable for free download at: www.librivox.org.

(Visited 1 times, 1 visits today)

Abraham Lincoln: A History Volume 8 by HAY, John and NICOLAY, John George

Abraham Lincoln: A History is an 1890 ten-volume account of the life and times of Abraham Lincoln, written by John Nicolay and John Hay, who were his personal secretaries during the American Civil War. Volume 8 chronicles Lincoln’s life from 1862 to 1863. (Summary adapted from wikipedia by Ann Boulais)
This title is avalable for free download at: www.librivox.org.

(Visited 1 times, 1 visits today)

Wayside and Woodland Trees: A pocket guide to the British sylva by STEP, Edward

“The purpose of this volume is not the addition of one more to the numerous treatises upon sylviculture or forestry, but to afford a straightforward means for the identification of our native trees and larger shrubs for the convenience of the rural rambler and Nature-lover. The list of British arborescent plants is a somewhat meagre one, but all that could be done in a pocket volume by way of supplementing it has been done—by adding some account of those exotics that have long been naturalized in our woods, and a few of more recent introduction that have already become conspicuous ornaments in many public and private parks.” From the Preface – Summary by KHand
This title is avalable for free download at: www.librivox.org.

(Visited 3 times, 1 visits today)

Interpreting ambiguous ‘trace’ results in <i>Schistosoma mansoni</i> CCA Tests: estimating sensitivity and specificity of ambiguous results with no gold standard

by Michelle N. Clements, Christl A. Donnelly, Alan Fenwick, Narcis B. Kabatereine, Sarah C. L. Knowles, Aboulaye Meité, Eliézer K. N’Goran, Yolisa Nalule, Sarah Nogaro, Anna E. Phillips, Edridah Muheki Tukahebwa, Fiona M. Fleming

Background

The development of new diagnostics is an important tool in the fight against disease. Latent Class Analysis (LCA) is used to estimate the sensitivity and specificity of tests in the absence of a gold standard. The main field diagnostic for Schistosoma mansoni infection, Kato-Katz (KK), is not very sensitive at low infection intensities. A point-of-care circulating cathodic antigen (CCA) test has been shown to be more sensitive than KK. However, CCA can return an ambiguous ‘trace’ result between ‘positive’ and ‘negative’, and much debate has focused on interpretation of traces results.

Methodology/Principle findings

We show how LCA can be extended to include ambiguous trace results and analyse S. mansoni studies from both Côte d’Ivoire (CdI) and Uganda. We compare the diagnostic performance of KK and CCA and the observed results by each test to the estimated infection prevalence in the population.Prevalence by KK was higher in CdI (13.4%) than in Uganda (6.1%), but prevalence by CCA was similar between countries, both when trace was assumed to be negative (CCAtn: 11.7% in CdI and 9.7% in Uganda) and positive (CCAtp: 20.1% in CdI and 22.5% in Uganda). The estimated sensitivity of CCA was more consistent between countries than the estimated sensitivity of KK, and estimated infection prevalence did not significantly differ between CdI (20.5%) and Uganda (19.1%). The prevalence by CCA with trace as positive did not differ significantly from estimates of infection prevalence in either country, whereas both KK and CCA with trace as negative significantly underestimated infection prevalence in both countries.

Conclusions

Incorporation of ambiguous results into an LCA enables the effect of different treatment thresholds to be directly assessed and is applicable in many fields. Our results showed that CCA with trace as positive most accurately estimated infection prevalence.

Tratto da: www.plos.org.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license.

(Visited 3 times, 1 visits today)

Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique

by Anna E. Phillips, Pedro H. Gazzinelli-Guimaraes, Herminio O. Aurelio, Josefo Ferro, Rassul Nala, Michelle Clements, Charles H. King, Alan Fenwick, Fiona M. Fleming, Neerav Dhanani

Background

In Mozambique, schistosomiasis is highly endemic across the whole country. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinates a five-year study that has been implemented in various African countries, including Mozambique. The overall goal of SCORE was to better understand how to best apply preventive chemotherapy with praziquantel (PZQ) for schistosomiasis control by evaluating the impact of alternative treatment approaches.

Methods

This was a cluster-randomised trial that compared the impact of different treatment strategies in study areas with prevalence among school children of ≥21% S. haematobium infection by urine dipstick. Each village was randomly allocated to one of six possible combinations of community-wide treatment (CWT), school-based treatment (SBT), and/or drug holidays over a period of four years, followed by final data collection in the fifth year. The most intense intervention arm involved four years of CWT, while the least intensive arm involved two years of SBT followed by two consecutive years of PZQ holiday. Each study arm included 25 villages randomly assigned to one of the six treatment arms. The primary outcome of interest was change in prevalence and intensity of S. haematobium among 100 children aged 9-to-12-years that were sampled each year in every village. In addition to children aged 9-to-12 years, 100 children aged 5–8 years in their first-year of school and 50 adults (aged 20–55 years) were tested in the first and final fifth year of the study. Prevalence and intensity of S. haematobium infection was evaluated by two filtrations, each of 10mL, from a single urine specimen.

Principal findings

In total, data was collected from 81,167 individuals across 149 villages in ten districts of Cabo Delgado province, Northern Mozambique. Overall PZQ treatment resulted in a significant reduction in the prevalence of S. haematobium infection from Year 1 to Year 5, where the average prevalence went from 60.5% to 38.8%, across all age groups and treatment arms. The proportion of those heavily infected also reduced from 17.6% to 11.9% over five years. There was a significantly higher likelihood of males being infected than females at baseline, but no significant difference between the sexes in their response to treatment. The only significant response based on a study arm was seen in both the 9-to-12-year-old and first-year cross sections, where two consecutive treatment holidays resulted in a significantly higher final prevalence of S. haematobium than no treatment holidays. When the arms were grouped together, four rounds of treatment (regardless of whether it was CWT or SBT), however, did result in a significantly greater reduction in S. haematobium prevalence than two rounds of treatment (i.e. with two intermittent or consecutive holiday years) over a five-year period.

Conclusions

Although PC was successful in reducing the burden of active infection, even among those heavily infected, annual CWT did not have a significantly greater impact on disease prevalence or intensity than less intense treatment arms. This may be due to extremely high starting prevalence and intensity in the study area, with frequent exposure to reinfection, or related to challenges in achieving high treatment coverage More frequent treatment had a greater impact on prevalence and intensity of infection when arms were grouped by number of treatments, however, cost efficiency was greater in arms only receiving two treatments. Finally, a significant reduction in prevalence of S. haematobium was seen in adults even in the SBT arms implying the rate of transmission in the community had been decreased, even where only school children have been treated, which has significant logistical and cost-saving implications for a national control programme in justifying CWT.

Tratto da: www.plos.org.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license.

(Visited 4 times, 1 visits today)

We are not Charlie and we will never be.