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Comparison of 3 optimized delivery strategies for completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV in Uganda: A single-center randomized trial

by Fred C. Semitala, Jillian L. Kadota, Allan Musinguzi, Fred Welishe, Anne Nakitende, Lydia Akello, Lynn Kunihira Tinka, Jane Nakimuli, Joan Ritar Kasidi, Opira Bishop, Suzan Nakasendwa, Yeonsoo Baik, Devika Patel, Amanda Sammann, Payam Nahid, Robert Belknap, Moses R. Kamya, Margaret A. Handley, Patrick PJ Phillips, Anne Katahoire, Christopher A. Berger, Noah Kiwanuka, Achilles Katamba, • Read More »


Estimating the impact of alternative programmatic cotrimoxazole strategies on mortality among children born to mothers with HIV: A modelling study

by Shrey Mathur, Melanie Smuk, Ceri Evans, Catherine J. Wedderburn, Diana M. Gibb, Martina Penazzato, Andrew J. Prendergast Background World Health Organization (WHO) guidelines recommend cotrimoxazole prophylaxis for children who are HIV-exposed until infection is excluded and vertical transmission risk has ended. While cotrimoxazole has benefits for children with HIV, there is no mortality benefit • Read More »


COVID-19 diagnostic testing and vaccinations among First Nations in Manitoba: A nations-based retrospective cohort study using linked administrative data, 2020–2021

by Nathan C. Nickel, Wanda Phillips-Beck, Jennifer E. Enns, Okechukwu Ekuma, Carole Taylor, Sarah Fileatreault, Nkiru Eze, Leona Star, Josée Lavoie, Alan Katz, Marni Brownell, Alyson Mahar, Marcelo Urquia, Dan Chateau, Lisa Lix, Mariette Chartier, Emily Brownell, Miyosha Tso Deh, Anita Durksen, Razvan Romanescu Background Differential access to healthcare has contributed to a higher burden • Read More »




Use of isotretinoin among girls and women of childbearing age and occurrence of isotretinoin-exposed pregnancies in Germany: A population-based study

by Jonas Reinold, Bianca Kollhorst, Nadine Wentzell, Katharina Platzbecker, Ulrike Haug Background Exposure to isotretinoin during pregnancy must be avoided due to its teratogenicity, but real-world data on its use are scarce. We aimed to describe (i) isotretinoin use in women of childbearing age in Germany; (ii) the occurrence of isotretinoin-exposed pregnancies; and (iii) malformations • Read More »


Burden of diarrhea and antibiotic use among children in low-resource settings preventable by Shigella vaccination: A simulation study

by Stephanie A. Brennhofer, James A. Platts-Mills, Joseph A. Lewnard, Jie Liu, Eric R. Houpt, Elizabeth T. Rogawski McQuade Background Shigella is a leading cause of diarrhea and dysentery in children in low-resource settings, which is frequently treated with antibiotics. The primary goal of a Shigella vaccine would be to reduce mortality and morbidity associated • Read More »


Suicide attempt and death by suicide among parents of young individuals with cancer: A population-based study in Denmark and Sweden

by Qianwei Liu, Krisztina D. László, Dang Wei, Fen Yang, Katja Fall, Unnur Valdimarsdóttir, Maria Feychting, Jiong Li, Fang Fang Background The psychological toll on parents of a child receiving a cancer diagnosis is known to be high, but there is a knowledge gap regarding suicidal behavior among these parents. The aim of this study • Read More »