clinical

Use of suboptimal control arms in randomized clinical trials of investigational cancer drugs in China, 2016–2021: An observational study

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by Yichen Zhang, Dingyi Chen, Siyuan Cheng, Zhizhou Liang, Lu Yang, Qian Li, Lin Bai, Huangqianyu Li, Wei Liu, Luwen Shi, Xiaodong Guan Background The use of suboptimal controls in randomized trials of new cancer drugs can produce potentially unreliable clinical efficacy results over the current standard of care and expose patients to substandard therapy. • Read More »

Mapping clinical interactions in an Australian tertiary hospital emergency department for patients presenting with risk of suicide or self-harm: Network modeling from observational data

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by Michael H. McCullough, Michael Small, Binu Jayawardena, Sean Hood Background Reliable assessment of suicide and self-harm risk in emergency medicine is critical for effective intervention and treatment of patients affected by mental health disorders. Teams of clinicians face the challenge of rapidly integrating medical history, wide-ranging psychosocial factors, and real-time patient observations to inform • Read More »