Tag: daniel

Ambient air pollution exposure and effects on neutralizing antibody titers following SARS-CoV-2 vaccination in adults – ​Daniel P. Croft

by Daniel P. Croft, Carl J. Johnston, Angela R. Branche, David Q. Rich, Philip K. Hopke, Kelly Thevenet-Morrison, Sally W. Thurston, Todd A. Jusko, Md Rayhanul Islam, Catherine Bunce, Michael C. Keefer, Edward E. Walsh, Ann R. Falsey

We examined the association between air pollution and neutralizing antibody responses to COVID-19 vaccination in participants enrolled in a phase 3 clinical trial. Seventy-four adults were vaccinated with two doses of the AstraZeneca ChAdOx1 vectored vaccine (AZD1222) (5 x 1010 viral particles) at baseline and day 29, between Aug 28, 2020, to Jan 15, 2021, in Monroe County, NY. SARS-CoV-2 pseudovirus neutralizing ID50 titers (NAb) and total spike protein IgG were assessed at baseline and 15, 29, 43, 57 and 90 days after vaccination. In this pilot study, each participant’s dates of neutralization titers were matched to Monroe County ambient concentrations of fine particles (PM2.5; ≤ 2.5 µm), black carbon (BC; marker of traffic), among other particulate and gaseous pollutants. Using linear mixed models, we estimated the association between each interquartile range (IQR) difference in air pollutant concentrations in the 14 days prior to blood collection and antibody responses at each post vaccination timepoint. Though not statistically significant, we observed a 23% reduction in NAb titer (95% CI: -67%, 79%) measured on day 43 (i.e., 14 days after second vaccination) associated with each 0.32 µg/m3 increase in BC concentrations in the prior 14 days. We also observed a 42% increase in spike protein IgG (95% CI: -16%, 141%) measured on day 15 (i.e., 14 days after primary vaccination) associated with each 0.26 µg/m3 increase in BC concentrations in the 14 days prior. A similar pattern for total spike protein IgG was observed at day 29 (42%; 95% CI: -22%, 157%) and 90 (43%; 95% CI: -11%, 127%). Future research will need to explore the possible association between air pollution exposure and antibody response to SARS-CoV-2 vaccination given the potential for compromised vaccine efficacy.

Correlates of cervical cancer awareness among women aged 30–49 in five sub-Saharan African nations: Evidence from the Demographic and Health Survey (DHS)—2017–2023 – ​Daniel J. Olivieri

by Daniel J. Olivieri, McKenna C. Eastment, Noleb Mugisha, Manoj P. Menon

Cervical cancer is the leading cause of cancer-related mortality in low- and middle-income countries (LMICs). Prior studies associate high cervical cancer awareness with reductions in cervical cancer incidence. In this study, we utilize nationally representative Demographic and Health Surveys Program (DHS) to analyze correlates of cervical cancer awareness to inform global strategies. All DHS surveys between 2017–2023 were queried for questions on cervical cancer awareness. Socio-demographic variables (e.g., age, marital status), socioeconomic variables (e.g., education, wealth, literacy) and variables pertaining to healthcare decision making, distance traveled, intimate partner violence (IPV), and female genital mutilation/circumcision (FGC/M)) were extracted. Sample weights were applied, and logistic regressions were performed. Variables with p 

Does disability modify the association between poor mental health and violence victimisation over adolescence? Evidence from the CoVAC cohort study in Uganda – ​Daniel J. Carter

by Daniel J. Carter, Charlie F. M. Pitcairn, Emily Eldred, Louise Knight, Janet Nakuti, Angel Mirembe, Lydia Atuhaire, Elizabeth Allen, Amiya Bhatia, Dipak Naker, Jenny Parkes, Karen Devries

We aimed to estimate the impact of poor mental health in early adolescence on subsequent poor mental health, depression, and violence victimisation in late adolescence and to determine whether young people living with disabilities experienced a stronger relationship between mental health and these outcomes. Data from two waves of a longitudinal cohort study of 2773 Ugandan adolescents were used to assess the impact of mental health difficulties in early adolescence (aged 11–14) on presence of subsequent mental health difficulties, depression and past year violence victimisation in later adolescence (aged 15–18). We used g-computation to examine how these outcomes changed dependent on levels of poor mental health in early adolescence and explored functional difficulties as an effect modifier. This study demonstrates high prevalence of mental health difficulties in adolescence. There is a positive association between mental health difficulties in early adolescence and experience of mental health difficulties, depression, and past year violence in later adolescence. The risk of poor outcomes is greater for individuals experiencing poorer mental health in early adolescence. The relationships between early mental health difficulties and both mental health difficulties in later adolescence and past year violence are stronger in young people with functional difficulties. Poor mental health in early adolescence is associated with depression and violence victimisation in later adolescence, and the association is stronger among adolescents living with disabilities. School-aged adolescents would benefit from violence prevention and mental health promotion interventions which are inclusive and engage and respond to the needs and rights of adolescents with disabilities.

Henderson, Daniel, 1880-1955Pirate Princes and Yankee Jacks Setting forth David Forsyth’s Adventures in America’s Battles on Sea and Desert with the Buccaneer Princes of Barbary, with an Account of a Search under the Sands of the Sahara Desert for the Treasure-filled Tomb of Ancient Kings

Pirate Princes and Yankee Jacks
Setting forth David Forsyth’s Adventures in America’s Battles on Sea and Desert with the Buccaneer Princes of Barbary, with an Account of a Search under the Sands of the Sahara Desert for the Treasure-filled Tomb of Ancient Kings
2020-09-05

Pirates — Juvenile fiction; United States. Navy — Juvenile fiction; Eaton, William, 1764-1811 — Juvenile fiction; United States — History — Tripolitan War, 1801-1805 — Juvenile fiction