Osteomalacia
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| Osteomalacia | |
|---|---|
| Classification and external resources | |
| ICD- 10 | M 83 |
| ICD- 9 | 268.2 |
| DiseasesDB | 9351 |
| eMedicine | ped/2014 radio/610 |
| MeSH | D010018 |
Osteomalacia is the general term for the softening of the bones due to defective bone mineralization. Osteomalacia in children is known as rickets, and because of this, osteomalacia is often restricted to the milder, adult form of the disease. It may show signs as diffuse body pains, muscle weakness, and fragility of the bones. A common cause of the disease is a deficiency in Vitamin D, which is normally obtained from the diet and/or sunlight exposure.
General characteristics
Osteomalacia in the adult is most commonly found in confined, dark-skinned, or diet-disbalanced subjects. Many of the effects of the disease overlap with the more common osteoporosis, but the two diseases are significantly different. Osteomalacia is specifically a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D.
Osteomalacia is derived from Greek: osteo refers to bone, and malacia means softness. In the past, the disease was also known as malacosteon and its Latin-derived equivalent, mollities ossium.
Causes
The causes of adult osteomalacia are varied.
- Insufficient sunlight exposure, especially in dark-skinned subjects
- Insufficient nutritional quantities or faulty metabolism of vitamin D or phosphorus
- Renal tubular acidosis
- Malnutrition during pregnancy
- Malabsorption syndrome
- Chronic renal failure
- Therapy with Fumaderm
Clinical features
Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs, spreading later to the arms and ribs. Pain is non-radiating, symmetrical, and accompanied by tenderness in the involved bones. Proximal muscles are weak, and there is difficulty in climbing up stairs and getting up from a squatting position. Physical signs include deformities like triradiate pelvis and lordosis. The patient has a typical "waddling gait". Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue and bone aches are not spontaneous but only revealed by pressure or shocks.
Biochemical findings
Biochemical features are similar to rickets.The major fact is a collapsed vitamin D rate in blood or serum.
Radiographic characteristics
Radiological appearances include
- pseudofractures
- protrusio acetabuli
Treatment
Nutritional osteomalacia responds well to administration of 200,000 IU weekly of vitamin D for 4 to 6 weeks, followed by a maintenance dose of 1600 IU daily or 200,000 IU every 4 to 6 months.
