Beth Quist – Grace

      Grace - Beth Quist

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Beth Quist – Monsters – MP3

      Monsters - Beth Quist

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Beth Quist – Om asatoma sad

      Om Asatoma Sad Gamaya - Beth Quist

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Beth Quist – Liquid Silver – MP3

      Liquid Silver - Beth Quist

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[GUIDA] Ecco come vedere la storia dei pacchetti installati, aggiornati o rimossi su Ubuntu, Debian o Mint

In questo articolo vediamo come scoprire tutti i pacchetti installati, aggiornati o rimossi dal vostro sistema. La guida, che si basa sull’uso della command line, è valida per Ubuntu, Linux Mint e Debian (e probabilmente per la maggior parte delle derivate).

L’obiettivo è accedere alla storia del vostro sistema, ovvero alla lista dei pacchetti DEB che avete installato / aggiornato / rimosso, compresa la data in cui l’avete fatto. Per farlo su Debian, Ubuntu e Linux Mint potete andare a leggere il file dpkg.log (dpkg è l’architettura di basso livello per la gestione, l’installazione e la rimozione dei pacchetti). Lo trovate nel percorso /var/log/dpkg.log. Potete usare il comando grep per il parse del file e quindi andare a visualizzare solo i pacchetti rimossi o quelli installati o quelli aggiornati, sulla base delle voste esigenze.

Questo metodo funziona per i pacchetti DEB qualsiasi sia il modo in cui li avete installati: graphical tool come Synaptic, Gnome Software, Update Manager, o un command line tool come apt, apt-get, aptitude o dpkg. Non funziona però per altri pacchetti come Flatpak o Snap, o per software installato dai sorgenti.

Aprite il terminale e date:

grep "install " /var/log/dpkg.log

Questo il risultato:

$ grep "install " /var/log/dpkg.log
2019-01-08 13:22:15 install automathemely:all <none> 1.3
2019-01-08 13:22:29 install python3-astral:all <none> 1.6.1-1
2019-01-08 13:22:29 install python3-tzlocal:all <none> 1.5.1-1
2019-01-08 13:22:29 install python3-schedule:all <none> 0.3.2-1

...

2019-01-09 17:19:49 install libwebkit2-sharp-4.0-cil:amd64 <none> 2.10.9+git20160917-1.1
2019-01-09 17:19:49 install sparkleshare:all <none> 3.28-1
2019-01-15 15:58:20 install ffsend:amd64 <none> 0.1.2

Analogamente potete dare

grep "upgrade " /var/log/dpkg.lo

per una lista dei pacchetti aggiornati.

Oppure

grep "remove " /var/log/dpkg.log

per la lista dei pacchetti rimossi.

/var/log/dpkg.log contiene i pacchetti installati, aggiornati e rimossi per il mese corrente. Per il mese precedente andate a leggere il file /var/log/dpkg.log.1

Ad esempio, date:

grep "install " /var/log/dpkg.log.1

Volete andare ancora più indietro? Usate zgrep al posto di grep e leggete /var/log/dpkg.log.2.gz, /var/log/dpkg.log.3.gz, /var/log/dpkg.log.4.gz e così via.

Esempio:

zgrep "upgrade " /var/log/dpkg.log.2.gz

Strade alternative

Ci sono metodi alternativi per raggiungere lo stesso obiettivo ma, come si dice dalle mie parti, “funzionicchiano”. Ad esempio Synaptic Package Manager (File -> History) può mostrarvi solo una storia dei pacchetti installati, aggiornati o rimossi mediante Synaptic stesso (e quindi non quelli aggiornati/installati/rimossi mediante apt, apt-get, dpkg, Software Updater,  etc). Analogamente il file di log /var/log/apt/history.log mostra solo le azioni svolte usando apt/apt-get.

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L’articolo [GUIDA] Ecco come vedere la storia dei pacchetti installati, aggiornati o rimossi su Ubuntu, Debian o Mint sembra essere il primo su Lffl.org.

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Senato della Repubblica – Voto regionale n. 23 – XVIII Legislatura – Assegnazione

Assegnato: <!– –>2ª Commissione permanente (Giustizia)<!– –>

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Mayor of Odessa could face criminal charges after his security attacked a local reporter

Odessa Mayor Gennadiy Trukhanov seconds before his security showed off Radio Svoboda reporter Mikhail Shtekel out of courthouse where he gave a press briefing. Screengrab from Shtekel's video posted on Twitter.

Odessa's police will investigate the city's mayor Gennady Trukhanov for “impeding the lawful professional activity of journalists”, a punishable offence by Ukraine's criminal code, following an incident in which his security detail physically assaulted a local reporter.

On December 27, Radio Svoboda journalist Mikhail Shtekel posed a question to Trukhanov at a press briefing, to which the mayor responded by pushing him away while his security proceeded to expel the journalist out of the building.

Shtekel, whose employer Radio Svoboda is the Ukrainian version of Radio Free Europe, recorded the whole incident on camera and posted the video on Twitter soon afterward:

Замість відповіді на запитання @radiosvoboda міський голова Одеси Генадій Труханов разом зі своєю охороною відпихнув мене і залишив приміщення Малиновського суду. Допомогала їм в цьому поліція. @NPU_GOV_UA @MVS_UA це 171-ша чи ні? pic.twitter.com/NRO7U7OohA

— Michael Shtekel (@mishajedi) December 27, 2018

Instead of answering the question by @radiosvoboda [Radio Liberty in Ukrainain] mayor of Odessa Gennadiy Trukhanov and his guards pushed me away and left Malinovskyi court building. They were helped to do it by the police. @NPU_GOV_UA [National Police] @MVS_UA [Ministry of Internal Affairs of Ukraine] does this fall under the Article 171 or not?

Article 171 of Ukraine's criminal code typifies the crime of “impeding lawful professional activity of journalists,” which covers illegal seizure of reporting materials, denial to provide access to information, among other actions. It imposes fines and a maximum prison time of three years.

On December 29, Shtekel stated, on his Facebook profile page, that with the help of his lawyers he had filed a criminal complaint related to Article 171 against Trukhanov, his guards, and the police officers who participated in the aggression. On January 2, the police of Odessa confirmed for Detector Media that they had initiated a criminal investigation of the incident.

The mayor's contempt for journalists

This is only the most recent episode in which Trukhanov or his subordinates have attacked journalists. In July 2018, when reporter Bogdan Osinskyi asked him why he had referred to a group of environmentalists as “green worms,” the mayor grabbed the journalist's phone and tried to hit him with it.

In April 2018, British journalist Andy Verity, who had come to Odessa with the BBC to report on a corruption probe that involves the mayor, was pushed, knocked down, and kicked in the groin by Trukhanov's security guards after he approached him with a question. The BBC has captured the whole incident on camera.

Finally, just before the end of 2018, Trukhanov said that Member of Parliament Mustafa Nayem, a former journalist, asks “stupid questions.”

Separately, Trukhanov is a defendant at an emblezzlement case related to the sale of Odessa's city hall building known as the Krayan plant. A trial began in October — the press briefing where Shtekel was attacked on December 27 followed a court hearing of this trial.

The mayor has also received harsh criticism, including in international fora, for the behavior of his “municipal guards”. Those are private security officers hired by the city of Odessa under suspicious circumstances who have been accused of multiple human rights violations, including against journalists.

Trukhanov is expected to run for re-election in 2020. However, if any of the criminal cases he's facing ends in conviction, he might find himself fighting for his own freedom rather than for his seat as mayor of Odessa.

On November 30, Trukhanov presented his own work in a positive light at an annual ceremony at Odessa's city hall. Such enthusiasm probably isn't shared by the city's journalists, for whom press freedom feels ever more elusive.

Written by Kanykei Tursunbaeva · comments (0)
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A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis

by Shakirat A. Adetunji, Gilbert Ramirez, Margaret J. Foster, Angela A. M. Arenas-Gamboa

Background

Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review the literature and perform a meta-analysis to estimate the global prevalence of osteoarticular brucellosis.

Methodology

Major bibliographic databases were searched using keywords and suitable combinations. All studies reporting the incidence and clinical manifestations of osteoarticular brucellosis in humans, and demonstrated by two or more diagnostic methods (bacteriological, molecular, serological, and/or radiographic) were included. Random effect model was used, and statistical significance was set at 0.5%

Principal findings

A total of 56 studies met the inclusion criteria and were included in the systematic review and meta-analysis. There was an evidence of geographical variation in the prevalence of osteoarticular disease with estimates ranging from 27% in low-risk regions to 36% in high-risk regions. However, the difference was not significant. Thus, brucellosis patients have at least 27% chance of developing osteoarticular disease.

Conclusions

The prevalence of OAB is not dependent on the endemicity of brucellosis in a particular region. Hence, further research should investigate the potential mechanisms of OAB, as well as the influence of age, gender, and other socioeconomic factor variations in its global prevalence, as this may provide insight into associated exposure risks and management of the disease.

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Surface molecules of extracellular vesicles secreted by the helminth pathogen <i>Fasciola hepatica</i> direct their internalisation by host cells

by Eduardo de la Torre-Escudero, Jared Q. Gerlach, Adam P. S. Bennett, Krystyna Cwiklinski, Heather L. Jewhurst, Kathryn M. Huson, Lokesh Joshi, Michelle Kilcoyne, Sandra O’Neill, John P. Dalton, Mark W. Robinson

Helminth parasites secrete extracellular vesicles (EVs) that can be internalised by host immune cells resulting in modulation of host immunity. While the molecular cargo of EVs have been characterised in many parasites, little is known about the surface-exposed molecules that participate in ligand-receptor interactions with the host cell surface to initiate vesicle docking and subsequent internalisation. Using a membrane-impermeable biotin reagent to capture proteins displayed on the outer membrane surface of two EV sub-populations (termed 15k and 120k EVs) released by adult F. hepatica, we describe 380 surface proteins including an array of virulence factors, membrane transport proteins and molecules involved in EV biogenesis/trafficking. Proteomics and immunohistochemical analysis show that the 120k EVs have an endosomal origin and may be released from the parasite via the protonephridial (excretory) system whilst the larger 15k EVs are released from the gastrodermal epithelial cells that line the fluke gut. A parallel lectin microarray strategy was used to profile the topology of major surface oligosaccharides of intact fluorogenically-labelled EVs as they would be displayed to the host. Lectin profiles corresponding to glycoconjugates exposed on the surface of the 15 K and 120K EV sub-populations are practically identical but are distinct from those of the parasite surface tegument, although all are predominated by high mannose sugars. We found that while the F. hepatica EVs were resistant to exo– and endo-glycosidases, the glyco-amidase PNGase F drastically remodelled the surface oligosaccharides and blocked the uptake of EVs by host macrophages. In contrast, pre-treatment with antibodies obtained from infected hosts, or purified antibodies raised against the extracellular domains of specific EV surface proteins (DM9-containing protein, CD63 receptor and myoferlin), significantly enhanced their cellular internalisation. This work highlights the diversity of EV biogenesis and trafficking pathways used by F. hepatica and sheds light on the molecular interaction between parasite EVs and host cells.

Tratto da: www.plos.org
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<i>Naja annulifera</i> Snake: New insights into the venom components and pathogenesis of envenomation

by Felipe Silva-de-França, Isadora Maria Villas-Boas, Solange Maria de Toledo Serrano, Bruno Cogliati, Sonia Aparecida de Andrade Chudzinski, Priscila Hess Lopes, Eduardo Shigueo Kitano, Cinthya Kimori Okamoto, Denise V. Tambourgi

Background

Naja annulifera is a medically important venomous snake occurring in some of the countries in Sub-Saharan Africa. Accidental bites result in severe coagulation disturbances, systemic inflammation and heart damage, as reported in dogs, and death, by respiratory arrest, in humans. Despite the medical importance of N. annulifera, little is known about its venom composition and the pathogenesis of envenomation. In this paper, the toxic, inflammatory and immunogenic properties of N. annulifera venom were analyzed.

Methodology/Principal findings

Venom proteomic analysis identified 79 different proteins, including Three Finger Toxins, Cysteine Rich Secretory Proteins, Metalloproteinases, Phospholipases A2 (PLA2), Hyaluronidase, L-amino-acid oxidase, Cobra Venom Factor and Serine Proteinase. The presence of PLA2, hyaluronidase, fibrinogenolytic and anticoagulant activities was detected using functional assays. The venom was cytotoxic to human keratinocytes. In an experimental murine model of envenomation, it was found that the venom induced local changes, such as swelling, which was controlled by anti-inflammatory drugs. Moreover, the venom caused death, which was preceded by systemic inflammation and pulmonary hemorrhage. The venom was shown to be immunogenic, inducing a strong humoral immune response, with the production of antibodies able to recognize venom components with high molecular weight and to neutralize its lethal activity.

Conclusions/Significance

The results obtained in this study demonstrate that N. annulifera venom contains toxins able to induce local and systemic inflammation, which can contribute to lung damage and death. Moreover, the venom is immunogenic, an important feature that must be considered during the production of a therapeutic anti-N. annulifera antivenom.

Tratto da: www.plos.org
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