by Marla I. Hertz, Hugues Nana-Djeunga, Joseph Kamgno, Abdel Jelil Njouendou, Valerine Chawa Chunda, Samuel Wanji, Amy Rush, Peter U. Fischer, Gary J. Weil, Philip J. Budge

The Global Program to Eliminate Lymphatic Filariasis (LF) relies on rapid diagnostic tests (RDTs) to determine where annual mass drug administration for LF is required and when it can be stopped. These tests detect a Wuchereria bancrofti glycoprotein in the blood of infected persons via (altro…)

by Joelma Carvalho Santos, Andrea Dória Batista, Carla Maria Mola Vasconcelos, Roberto Souza Lemos, Valter Romão de Souza Junior, Alain Dessein, Hélia Dessein, Silvia Maria Lucena Montenegro, Edmundo Pessoa Almeida Lopes, Ana Lúcia Coutinho Domingues

Background

ARFI elastrography has been used as a noninvasive method to assess the severity of liver fibrosis in viral hepatitis, although with few studies in schistosomiasis mansoni. We aimed to evaluate the performance of point shear wave (altro…)

by Yisha Liang, Xuezhi Cao, Qiang Ding, Yanan Zhao, Zhenliang He, Jin Zhong

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by Vivek Nanda, Ting Wang, Milos Pjanic, Boxiang Liu, Trieu Nguyen, Ljubica Perisic Matic, Ulf Hedin, Simon Koplev, Lijiang Ma, Oscar Franzén, Arno Ruusalepp, Eric E. Schadt, Johan L. M. Björkegren, Stephen B. Montgomery, Michael P. Snyder, Thomas Quertermous, Nicholas J. Leeper, Clint L. Miller

Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial wall-specific mechanisms. One of the annotated (altro…)

by Neeraj Sharma, Taylor A. Evans, Matthew J. Pellicore, Emily Davis, Melis A. Aksit, Allison F. McCague, Anya T. Joynt, Zhongzhu Lu, Sangwoo T. Han, Arianna F. Anzmann, Anh-Thu N. Lam, Abigail Thaxton, Natalie West, Christian Merlo, Laura B. Gottschalk, Karen S. Raraigh, Patrick R. Sosnay, Calvin U. Cotton, Garry R. Cutting

CFTR modulators have revolutionized the treatment of individuals with cystic fibrosis (CF) by improving the function of existing protein. Unfortunately, (altro…)

by Andrej Berg, Oleksandra Kukharenko, Martin Scheffner, Christine Peter

Covalent modification of proteins by ubiquitin or ubiquitin chains is one of the most prevalent post-translational modifications in eukaryotes. Different types of ubiquitin chains are assumed to selectively signal respectively modified proteins for different fates. In support of this hypothesis, structural studies have shown that the eight possible ubiquitin dimers adopt different conformations. However, at least in some cases, these structures cannot sufficiently (altro…)

by Joana C. Xavier, Kiran Raosaheb Patil, Isabel Rocha

Essential metabolic reactions are shaping constituents of metabolic networks, enabling viable and distinct phenotypes across diverse life forms. Here we analyse and compare modelling predictions of essential metabolic functions with experimental data and thereby identify core metabolic pathways in prokaryotes. Simulations of 15 manually curated genome-scale metabolic models were integrated with 36 large-scale gene essentiality datasets encompassing a wide variety of species of (altro…)

by The PLOS Biology Staff

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Note sul Copyright: Articles and accompanying materials published by PLOS on the PLOS Sites, unless otherwise indicated, are licensed by the respective authors of such articles for use and distribution by you subject to citation of the original source in accordance with the Creative Commons Attribution (CC BY) license.

by Sisi Zheng, Guolin Ma, Lian He, Tian Zhang, Jia Li, Xiaoman Yuan, Nhung T. Nguyen, Yun Huang, Xiaoyan Zhang, Ping Gao, Robert Nwokonko, Donald L. Gill, Hao Dong, Yubin Zhou, Youjun Wang

The endoplasmic reticulum (ER) Ca²⁺ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca²⁺ depletion with extracellular Ca²⁺ influx, are crucial for the maintenance of Ca²⁺ homeostasis in mammalian cells. Despite the recent progress in unraveling (altro…)